Nature rune

Nature runes are used for transformation spells such as Alchemy Spells, bones to peaches, and Super-Heat Item. There are two types of alchemy spells: Low Alchemy and High Alchemy.

High alchemy gives you the amount of money if the item was sold at a specialty shop, and low alchemy gives you the amount of money if the item was sold in the general store. The items that you can't use alchemy on are usually quest or non-tradeable items. You can also runecrafting nature runes if you have pure essence, a nature tiara or talisman, and level 44 runecrafting. If you have 91 Runecrafting, you can craft double natures for an essence.